The Prahl Lab at UCSF is dedicated to advancing the understanding of immune responses to infectious diseases, with a particular focus on vulnerable populations such as pregnant individuals, infants, and children.

The lab conducts cutting-edge research in maternal and child health, investigating how the immune system develops and functions during critical periods of life, including pregnancy and early childhood. A major aspect of their work involves studying adaptive immune responses to infections and vaccinations including COVID-19, RSV, CMV, and malaria which disproportionately impact these groups and can lead to severe disease outcomes. By examining the interplay between host immunity and pathogens, the Prahl Lab seeks to uncover mechanisms that can inform the development of vaccines and other preventative measures. They are particularly interested in optimizing maternal immunization strategies to protect both mothers and their infants, as well as improving vaccine efficacy and durability in young children.

Through their work, the Prahl Lab aims to contribute to global health initiatives by reducing the burden of infectious diseases in underserved and high-risk populations, ultimately paving the way for innovative approaches to disease prevention and treatment.